| dw | vw | 2e jaargang nummer 16, zaterdag 17 april 2021 | a.w. | h.p | score |
| 1 | 1 | BLIJVEN SLAPEN — Snelle x Maan | 6 | 4×1 | 273 |
| 2 | 4 | GOUD — Suzan & Freek | 5 | 2 | 201 |
| 3 | 2 | WELLERMAN (220Kid x Billen Ted Remix) — Nathan Evans | 10 | 2×1 | 422 |
| 4 | 3 | FRIDAY — Riton x Nightcrawlers | 8 | 3 | 320 |
| 5 | 5 | WITHOUT YOU — The Kid Laroi | 15 | 3 | 656 |
| 6 | 7 | HOLD ON — Justin Bieber | 5 | 6 | 171 |
| 7 | 9 | YOUR LOVE (9PM) — Atb x Topic x a7s | 11 | 7 | 354 |
| 8 | 19 | PEACHES — Justin Bieber feat. Daniel Caesar & Giveon | 3 | 8 | 88 |
| 9 | 6 | DRIVERS LICENSE — Olivia Rodrigo | 13 | 2 | 589 |
| 10 | 8 | ALL WE GOT — Robin Schulz feat. Kiddo | 14 | 5 | 567 |
| 11 | 12 | LEAVE THE DOOR OPEN — Bruno Mars, Anderson .Paak, Silk Sonic | 4 | 11 | 134 |
| 12 | 10 | THE BUSINESS — Tiësto | 26 | 1×1 | 1124 |
| 13 | 13 | HYPNOTIZED — Purple Disco Machine (F) | 12 | 13 | 322 |
| 14 | 18 | COVER ME IN SUNSHINE — P!nk + Willow Sage Hart | 6 | 14 | 165 |
| 15 | 11 | NU WIJ NIET MEER PRATEN — Jaap Reesema & Pommelien Thijs | 20 | 10×1 | 903 |
| 16 | 14 | ALS IK JE WEER ZIE — Thomas Acda / Paul de Munnik / Maan / Typhoon (F) | 12 | 8 | 441 |
| 17 | 21 | ASTRONAUT IN THE OCEAN — Masked Wolf | 5 | 17 | 111 |
| 18 | 15 | PARADISE — Meduza & Dermot Kennedy | 17 | 5 | 648 |
| 19 | 25 | FLOATING THROUGH SPACE — Sia x David Guetta | 9 | 19 | 180 |
| 20 | 22 | WE’RE GOOD — Dua Lipa | 7 | 20 | 173 |
| 21 | 16 | LOVE NOT WAR – THE TAMPA — Jason Derulo x Nuka | 16 | 7 | 585 |
| 22 | — | MONTERO (CALL ME BY YOUR NAME) — Lil Nas X | 1 | 22 | 29 |
| 23 | 24 | 1 OP EEN MILJOEN – Metejoor feat. Babet | 9 | 23 | 187 |
| 24 | 17 | 501 — Bilal Wahib feat. Ronnie Flex | 6 | 14 | 163 |
| 25 | 29 | LITTLE BIT OF LOVE — Tom Grennan | 4 | 25 | 65 |
| 26 | 23 | SAVE YOUR TEARS — The Weeknd (F) | 27 | 13 | 705 |
| 27 | 20 | ANYONE — Justin Bieber | 14 | 7 | 516 |
| 28 | 28 | HEAD & HEART — Joel Corry & Mnek | 36 | 2 | 1509 |
| 29 | 35 | BED — Joel Corry x David Guetta x Raye | 3 | 29 | 42 |
| 30 | 42 | FOLLOW YOU — Imagine Dragons | 3 | 30 | 42 |
| 31 | 27 | GET OUT MY HEAD — Shane Codd | 13 | 17 | 364 |
| 32 | 41 | VUURWERK — Camille [Be] | 2 | 32 | 29 |
| 33 | 26 | AFTERGLOW — Ed Sheeran | 15 | 9 | 513 |
| 34 | 32 | LEARNING TO FLY – Sheppard (F) | 11 | 21 | 218 |
| 35 | 31 | VEN VEN — Rolf Sanchez | 7 | 30 | 126 |
| 36 | 33 | FEVER — Dua Lipa feat. Angele | 16 | 21 | 403 |
| 37 | 38 | HEAD SHOULDERS KNEES & TOES — Ofenbach & Quarterhead (feat. Norma Jean Martine) | 25 | 3 | 732 |
| 38 | 34 | MY HEAD & MY HEART — Ava Max (F) | 9 | 34 | 98 |
| 39 | 36 | GOOSEBUMPS — Hvme | 14 | 10 | 394 |
| 40 | 37 | RISE — Lost Frequencies | 3 | 37 | 28 |
| 41 | 45 | TRANEN — Kris Kross Amsterdam, Kraantje Pappie & Pommelien Thijs | 2 | 41 | 16 |
| 42 | — | FRANS DUITS — Donnie & Frans Duijts | 1 | 42 | 9 |
| 43 | 30 | EEN MOMENT — Marco Borsato & Rolf Sanchez & John Ewbank (F) | 5 | 16 | 112 |
| 44 | — | SEVENTEEN — Krezip (F) | 1 | 44 | 7 |
| 45 | 40 | EN ROUTE — Cleymans & Van Geel | 5 | 40 | 38 |
| 46 | 46 | HORIZON – Blof (F) | 2 | 46 | 10 |
| 47 | 48 | CAN’T BREAK A BROKEN HEART — Olivia [Be] | 3 | 42 | 16 |
| 48 | 44 | THE WRONG PLACE — Hooverphonic | 5 | 35 | 56 |
| 49 | — | FISHERMAN — Kevin [NL] | 1 | 49 | 2 |
| 50 | — | IK MIS JE NIET — Tino Martin | 1 | 50 | 1 |
| Kijk voor de uitzendende stations op www.flitsende50.nl/stations/ | |||||
| Uitzending of overname alleen naar toestemming van Flitsende 50, Postbus 3323, ‘s-Hertogenbosch |