| dw | vw | 2e jaargang nummer 42, zaterdag 16 oktober 2021 (nummer 93) | a.w. | h.p | score |
| 1 | 3 | COLD HEART — Elton John & Dua Lipa (F) | 8 | 1×1 | 324 |
| 2 | 8 | PEPAS — Farruko | 6 | 2 | 226 |
| 3 | 1 | SHIVERS — Ed Sheeran | 4 | 1×1 | 170 |
| 4 | 2 | LOVE TONIGHT — Shouse | 12 | 1×1 | 540 |
| 5 | 4 | STAY — The Kid Laroi & Justin Bieber | 13 | 2×1 | 616 |
| 6 | 7 | WHERE ARE YOU NOW — Lost Frequencies / Calum Scott | 7 | 6 | 247 |
| 7 | 5 | BAD HABITS — Ed Sheeran | 15 | 6×1 | 722 |
| 8 | 6 | BON GEPAKT — Donnie feat. Rene Froger | 5 | 6 | 173 |
| 9 | 11 | HEAT WAVES — Glass Animals | 4 | 9 | 120 |
| 10 | 12 | NEVER GOING HOME – Kungs | 10 | 7 | 333 |
| 11 | 18 | LOVE NWANTITI (AH AH AH) — CKay feat. Joeboy & Kuami Eugene | 4 | 11 | 102 |
| 12 | 10 | TAKE MY BREATH — The Weeknd (F) | 9 | 3×1 | 405 |
| 13 | 9 | IK GA ZWEMMEN — Mart Hoogkamer | 9 | 5 | 385 |
| 14 | 13 | RUN — Onerepublic | 15 | 8 | 538 |
| 15 | 32 | THAT’S WHAT I WANT — Lil Nas X | 2 | 15 | 55 |
| 16 | 14 | REMEMBER — Becky Hill & David Guetta (F) | 15 | 9 | 559 |
| 17 | 15 | UHUH — $hirak feat. Ronnie Flex, Yssi SB & Lil Kleine | 8 | 14 | 246 |
| 18 | 16 | DON’T GO YET – Camila Cabello | 10 | 14 | 321 |
| 19 | 39 | MY UNIVERSE — Coldplay x BTS | 2 | 19 | 44 |
| 20 | 17 | ZOLANG JE BIJ ME BENT (F) — Jan Smit | 6 | 15 | 193 |
| 21 | 34 | SOMETHING I NEED TO KNOW — Soulsister (F) | 2 | 21 | 47 |
| 22 | 25 | HURRICANE — Ofenbach & Ella Henderson (F) | 3 | 22 | 69 |
| 23 | 22 | RENDEZ-VOUS — Metejoor & Emma Heesters | 17 | 19 | 418 |
| 24 | 19 | HET LEVEN IS TE KORT — Waylon (F) | 4 | 19 | 100 |
| 25 | 20 | I STILL HAVE FAITH IN YOU — Abba (F) | 5 | 10 | 163 |
| 26 | 21 | GOOD 4 YOU — Olivia Rodrigo | 20 | 4×1 | 856 |
| 27 | 24 | ONDERWEG NAAR LATER — Suzan & Freek | 13 | 8 | 434 |
| 28 | 42 | DUIZEND STERREN — Regi & Pauline | 2 | 28 | 32 |
| 29 | 27 | CHASING STARS – No Strings Attached | 4 | 27 | 73 |
| 30 | 35 | WOMAN — Doja Cat | 7 | 30 | 89 |
| 31 | 36 | OUT OUT — joel corry x jax jones feat. charli xc | 3 | 31 | 39 |
| 32 | 31 | LEAVE BEFORE YOU LOVE ME — Marshmello x Jonas Brothers | 11 | 26 | 196 |
| 33 | 23 | TROMPETISTO – Sjaak | 8 | 19 | 207 |
| 34 | 43 | DON’T BE SHY — Tiësto & Karol G | 2 | 34 | 25 |
| 35 | 26 | LOVE AGAIN — Dua Lipa | 16 | 6 | 591 |
| 36 | 28 | INDUSTRY BABY — Lil Nas X & Jack Harlow | 8 | 22 | 173 |
| 37 | — | WHO’S IN YOUR HEAD — Jonas Brothers (F) | 1 | 37 | 14 |
| 38 | 33 | SUMMER OF LOVE — Shawn Mendes & Tainy | 6 | 27 | 108 |
| 39 | 38 | SAMEN — Kevin feat. Yade Lauren | 4 | 38 | 41 |
| 40 | 29 | NIKS IS HEILIG — Maan | 7 | 26 | 132 |
| 41 | — | IBIZA — Bilal Wahib | 1 | 41 | 10 |
| 42 | 30 | SKATE — Bruno Mars, Anderson Paak, Silk Sonic (F) | 10 | 14 | 263 |
| 43 | — | VREEMDE VOOR MIJ — Sigourney K feat. Sevn Alias | 1 | 43 | 8 |
| 44 | 37 | VUURWERK — Camille [Be] | 28 | 21 | 575 |
| 45 | 40 | VISITING HOURS — Ed Sheeran (F) | 7 | 24 | 116 |
| 46 | 46 | LAST TRAIN HOME — John Mayer | 15 | 27 | 150 |
| 47 | re | HARD TO SAY GOODBYE — Rondé | 2 | 45 | 10 |
| 48 | 49 | STERKER — Niels Destadsbarder | 3 | 48 | 6 |
| 49 | 41 | HERO — Afrojack & David Guetta (F) | 23 | 11 | 646 |
| 50 | — | GEEF JE HART NIET ZOMAAR WEG — Racoon | 1 | 50 | 1 |